Paclitaxel
货号：
10461-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 10461-5mg |
| 描述 | Paclitaxel, a potent disruptor of microtubules derived from the bark of the Pacific yew tree, is widely used as a chemotherapeutic compound. Tested against a panel of cervical (HeLa), lung (A549), breast (MCF-7), colon (HT-29), ovarian (OVG-1), and pancreatic (PC-Sh) carcinomas, paclitaxel demonstrates IC50 values ranging from 2.5-7.5 nM.1 Paclitaxel disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1.2 It initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.3 |
| 别名 | NSC 125973; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liebmann, J.E.,Cook, J.A.,Lipschultz, C., et al. Cytotoxic studies of paclitaxel (Taxol) in human tumour cell lines. Br. J. Cancer 68(6), 1104-1109 (1993).
2.Woods, C.M.,Zhu, J.,McQueney, P.A., et al. Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathway. Mol. Med. 1(5), 506-526 (1995).
3.Wang, T.h.,Wang, H.S. and Soong, Y.K. Paclitaxel-induced cell death: Where the cell cycle and apoptosis come together. Cancer 88(11), 2619-2628 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 853.9 |
| 分子式 | C47H51NO14 |
| CAS号 | 33069-62-4 |
| 稳定性 | ≥ 2 years |
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