| 货号 | 10458-100ug |
| 描述 | Dihomo-γ-Linolenic Acid-d6(DGLA-d6) contains six deuterium atoms at the 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of DGLA by GC- or LC-mass spectrometry. Dihomo-γ-Linolenic Acid (DGLA, 20:3), an elongation product of γ-linolenic acid (18:3), is rapidly metabolized by fatty acid desaturases to produce arachidonic acid (20:4). DGLA is metabolized through the cyclooxygenase pathway to produce 1-series prostaglandins, (PGs), including PGE1.1,2 In mice, DGLA supplementation in the diet can reduce atopic dermatitis and atherosclerosis.3,4 |
| 别名 | DGLA-d6; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Bell, J.G.,Tocher, D.R. and Sargent, J.R. Effect of supplementation with 20:3(n-3), 20:4(n-6) and 20:5(n-3) on the production of prostaglandins E and F of the 1-, 2- and 3-series in turbot (Scophthalmus maximus) brain astroglial cells in primary culture. Biochimica et Biophysica Acta 1211, 335-342 (1994). 2.Levin, G.,Duffin, K.L.,Obukowicz, M.G., et al. Differential metabolism of dihomo-γ-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: Implications for cellular synthesis of prostaglandin E1 and prostaglandin E2. Biochemistry Journal 365, 489-496 (2002). 3.Kawashima, H.,Tateishi, N.,Shiraishi, A., et al. Oral administration of dihomo-γ-linolenic acid prevents development of atopic dermatitis in NC/Nga mice. Lipids 43(1), 37-43 (2007). 4.Takai, S.,Jin, D.,Kawashima, H., et al. Anti-atherosclerotic effects of dihomo-γ-linolenic acid in ApoE-deficient mice. J.Atheroscer.Thromb. 16(4), 480-489 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d6) |
| 计算分子量 | 312.5 |
| 分子式 | C20H28D6O2 |
| CAS号 | 81540-86-5 |
| 稳定性 | ≥ 1 year |
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