| 货号 | 10253-10mg |
| 描述 | Doxifluridine is an intermediary prodrug of fluorouracil (Item No. 14416), the pyrimidine analog that inhibits thymidylate synthase selectively in tumor cells, interfering with DNA synthesis.1,2,3,4 Doxifluridine is one of two intermediary metabolites formed during metabolic conversion of the chemotherapeutic prodrug, capecitabine (Item No. 10487), to fluorouracil.4 |
| 别名 | 5-DFUR;Ro 21-9738; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Ozawa, S.,Hamada, M.,Murayama, N., et al. Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver. Cancer Chemotherapy and Pharmacology 50, 454-458 (2002). 2.Kato, Y.,Onishi, H. and Machida, Y. Contribution of chitosan and its derivatives to cancer chemotherapy. In Vivo 19, 301-310 (2005). 3.Konishi, H.,Yoshimoto, T.,Morita, K., et al. Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats. Journal of Pharmacy and Pharmacology 55, 143-149 (2003). 4.Miwa, M.,Ura, M.,Nishida, M., et al. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. European Journal of Cancer 34(8), 1274-1281 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 246.2 |
| 分子式 | C9H11FN2O5 |
| CAS号 | 436349 |
| 稳定性 | ≥ 2 years |
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