BAY u3405
货号：
10156-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10156-1mg |
| 描述 | The biological effects of prostaglandin D2(PGD2; Item No. 12010) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and DP2/CRTH2. BAY u3405 (Ramatroban) is an approved human medication for the treatment of allergic rhinitis that has documented activity as an antagonist of the thromboxane receptor (TP receptor).1 BAY u3405 is also an antagonist of the DP2 receptor with IC50 values of 100-170 nM.2 BAY u3405 is more potent at the DP2 receptor than the TP receptor by 4-5 fold. BAY u3405 is therefore a useful tool for the elucidation of PGD2/DP2 function in eosinophils, basophils, and other cells of the TH2 cell-type. |
| 别名 | Ramatroban; |
性能| 供应商 | Cayman |
| 应用文献 |
1.McKenniff, M.G.,Norman, P.,Cuthbert, N.J., et al. BAY u3405, a potent and selective thromboxane A2 receptor antagonist on airway smooth muscle in vitro. British Journal of Pharmacology 104(3), 585-590 (1991).
2.Sugimoto, H.,Shichijo, M.,Iino, T., et al. An orally bioavailable small molecule antagonist of CRTH2, Ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro. Journal of Pharmacology and Experimental Therapeutics 305, 347-352 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 416.5 |
| 分子式 | C21H21FN2O4S |
| CAS号 | 116649-85-5 |
| 稳定性 | ≥ 2 years |
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