| 货号 | 10135-1mg |
| 描述 | ICI 192605 is a potent antagonist of the thromboxane A2 receptor (TP) that blocks contraction of isolated guinea pig trachea induced by U-46619 (Item No. 16450; Kd = 0.398 nM).1,2 It is used to study the role of TP signaling in tissues and animals.3,4,5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brewster, A.G.,Brown, G.R.,Foubister, A.J., et al. The synthesis of a novel thromboxane receptor antagonist 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid ICI 192605. Prostaglandins 36(2), 173-178 (1988). 2.Dubuffet, T.,Muller, O.,Simonet, S.S., et al. Synthesis of new 3,4-disubstituted pyrrolidines as thromboxane A2/prostaglandin H2 (TP) receptor antagonists. Bioorg. Med. Chem. Lett. 6(4), 349-352 (1996). 3.Hausermann, L. and St-Louis, J. Thromboxane and isoprostane share the same prostanoid receptors to increase human placental tone. Placenta 32(12), 941-948 (2011). 4.Hewitt, M.M.,Adams, G., Jr.,Mazzone, S.B., et al. Pharmacology of bradykinin-evoked coughing in guinea pigs. J. Pharmacol. Exp. Ther. 357(3), 620-628 (2016). 5.Janssen, L.J. and Tazzeo, T. Involvement of TP and EP3 receptors in vasoconstrictor responses to isoprostanes in pulmonary vasculature. Journal of Pharmacology and Experimental Therapeutics 301(3), 1060-1066 (2002). 6.Pettipher, R.,Hansel, T.T. and Armer, R. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat. Rev. Drug Discov. 6, 313-325 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 402.9 |
| 分子式 | C22H23ClO5 |
| CAS号 | 117621-64-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |