MK-886 (sodium salt)
货号：
10133-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10133-1mg |
| 描述 | Arachidonic acid (Item No. 90010) and selected other polyunsaturated fatty acids are stereoselectively oxygenated at carbon 5 by the non-heme iron containing enzyme 5-lipoxygenase (5-LO).1 The intervention of a second protein, 5-LO-activating protein (FLAP), is required before 5-LO can become catalytically active.2 MK-886 binds to FLAP with high-affinity and prevents 5-LO activation. MK-886 inhibits leukotriene biosynthesis in leukocytes with an IC50 of 2.5 nM.3 In human whole blood, leukotriene biosynthesis is inhibited by MK-886 with an IC50 of 1.1 µM. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ford-Hutchinson, A.W.,Gresser, M. and Young, R.N. 5-Lipoxygenase. Annual Reviews of Biochemistry 63, 383-417 (1994).
2.Abramovitz, M.,Wong, E.,Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. European Journal of Biochemistry 215, 105-111 (1993).
3.Dixon, R.A.F.,Diehl, R.E.,Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343, 282-284 (1990).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 494.1 |
| 分子式 | C27H33ClNO2S • Na |
| CAS号 | 118427-55-7 |
| 稳定性 | ≥ 1 year |
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