| 货号 | 10075-1mg |
| 描述 | Inhibitors of cyclooxygenase (COX) are generally grouped according to selectivity for COX-1 versusCOX-2.1,2 However, many COX inhibitors also show an antitumor, pro-apoptotic activity that is distinct from COX inhibition - celecoxib is an example.3 CAY10452 is a celecoxib analog that retains potent, selective COX-2 inhibitory activity (IC50 = 32 nM), but does not induce apoptosis in prostate cancer cell lines even at 100 µM.4 CAY10452 is thus a clean, selective tool for the inhibition of COX-2. |
| 别名 | PTPBS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Khanna, I.K.,Yu, Y.,Huff, R.M., et al. Selective cyclooxygenase-2 inhibitors: Heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents. Journal of Medicinal Chemistry 43, 3168-3185 (2000). 2.FitzGerald, G.A. and Loll, P. COX in a crystal ball: Current status and future promise of prostaglandin research. Journal of Clinical Investigation 107(11), 1335-1337 (2001). 3.Dempke, W.,Rie, C.,Grothey, A., et al. Cyclooxygenase-2: A novel target for cancer chemotherapy? Journal of Cancer Research and Clinical Oncology 127, 411-417 (2001). 4.Song, X.,Lin, H.P.,Johnson, A.J., et al. Cyclooxygenase-2, player or spectator in cyclooxygenase-2 inhibitor-induced apoptosis in prostate cancer cells. Journal of the National Cancer Institute 94(8), 585-591 (2002). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 367.3 |
| 分子式 | C16H12F3N3O2S |
| CAS号 | 170569-87-6 |
| 稳定性 | ≥ 2 years |
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