| 货号 | 10029-1mg |
| 描述 | The cysteinyl leukotrienes (CysLTs), leukotriene (LTC4), LTD4, and LTE4, mediate their actions through two distinct G protein-coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2receptor.1,2 MK-571 is a selective, orally active CysLT1 receptor antagonist.3 It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT1 receptor-mediated activity in these preparations.3 MK-571 effectively blocks LTD4 activation of recombinant human and murine CysLT1receptors1,4 but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2receptors.2,4 |
| 别名 | L-660,711; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lynch, K.R.,ONeill, G.P.,Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999). 2.Heise, C.E.,ODowd, B.F.,Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000). 3.Jones, T.R.,Zamboni, R.,Belley, M., et al. Pharmacology of L-660,711 (MK-571): A novel potent and selective leukotriene D4 receptor antagonist. Canadian Journal of Physiology and Pharmacology 67, 17-28 (1989). 4.Ogasawara, H.,Ishii, S.,Yokomizo, T., et al. Characterization of mouse cysteinyl leukotriene receptors mCysLT1 and mCysLT2. Differential pharmacological properties and tissue distribution. The Journal of Biological Chemisty 277(21), 18763-18768 (2002). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 515.1 |
| 分子式 | C26H27ClN2O3S2 |
| CAS号 | 115104-28-4 |
| 稳定性 | ≥ 2 years |
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