KB2115
货号：
10011054-500ug 基本售价：
350.0 元 规格：
500 ug
产品信息
概述| 货号 | 10011054-500ug |
| 描述 | The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), promote the reduction of plasma cholesterol levels and induce weight loss. However when administered in high doses, thyroid hormones produce undesirable side effects in the heart, bone and muscle. KB2115 is a synthetic thyroid hormone mimetic. At a dose of 50-200 µg administered to humans once-daily for 14 days, KB2115 lowers total and low-density lipoprotein cholesterol up to 40% without affecting high-density lipoprotein cholesterol levels and without deleterious side effects to the cardiovascular system.1 Unlike the statin class of drugs which decrease cholesterol synthesis, KB2115 stimulates cholesterol catabolism to bile acids without affecting cholesterol synthesis.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Berkenstam, A.,Kristensen, J.,Mellström, K., et al. The thyroid hormone mimetic compound KB2115 lowers plasma LDL cholesterol and stimulates bile acid synthesis without cardiac effects in humans. Proceedings of the National Academy of Sciences of the United States of America 105(2), 663-667 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 487.1 |
| 分子式 | C18H17Br2NO5 |
| CAS号 | 355129-15-6 |
| 稳定性 | ≥ 2 years |
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