| 货号 | 10010622-10mg |
| 描述 | Uncoupling protein 2 (UCP2) is a mitochondrial carrier protein that is expressed in pancreatic islets and has been shown to negatively regulate glucose-stimulated insulin secretion.1,2 High levels of UCP2 expression can disrupt pancreatic β cell function and downregulate insulin secretion thereby contributing to the development of type 2 diabetes.3 Genipin, a compound isolated from Gardenis jasminoides Ellis fruits, was originally identified as a protein cross-linking agent. Genipin is a cell-permeable inhibitor of UCP2 activity.4 Genipin, at 5 µM, increases glucose-stimulated insulin secretion in isolated pancreatic islets chronically exposed to high levels of glucose.5 Genipin also exhibits anti-inflammatory and anti-angiogenic properties by inducing apoptosis in FaO rat hepatoma cells and human hepatocarcinoma Hep3B cells.6 |
| 别名 | (+)-Genipin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chan, C.B.,De Leo, D.,Joseph, J.W., et al. Increased uncoupling protein-2 levels in ß-cells are associated with impaired glucose-stimulated insulin secretion mechanism of action. Diabetes 50, 1302-1310 (2001). 2.Zhang, C.Y.,Baffy, G.,Perret, P., et al. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, ß cell dysfunction, and type 2 diabetes. Cell 105, 745-755 (2001). 3.Sesti, G.,Cardellini, M.,Marini, M.A., et al. A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52, 1280-1283 (2003). 4.Parton, L.E.,Ye, C.P.,Coppari, R., et al. Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449, 228-232 (2007). 5.Zhang, C.Y.,Parton, L.E.,Ye, C.P., et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity-and high glucose-induced ß cell dysfunction in isolated pancreatic islets. Cell Metabolism 3, 417-427 (2006). 6.Kim, B.C.,Kim, H.G.,Lee, S.A., et al. Genipin-induced apoptosis in hepatoma cells is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of mitochondrial pathway. Biochemical Pharmacology 70, 1398-1407 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 226.2 |
| 分子式 | C11H14O5 |
| CAS号 | 6902-77-8 |
| 稳定性 | ≥ 2 years |
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