TMP-153
货号：
10010516-5mg 基本售价：
350.0 元 规格：
5 mg
产品信息
概述| 货号 | 10010516-5mg |
| 描述 | Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues. ACAT inhibitors improve plasma lipid profile and ameliorate proteinuria in nephrotic animals.1 TMP-153 is a quinolyl derivative that inhibits ACAT with IC50 values of 5-10 nM in various animals.2 At 0.5-1.5 mg/kg, TMP-153 dose-dependently reduces plasma total- and low density lipoprotein cholesterol without affecting high density lipoprotein cholesterol in hamsters.2 It inhibits cholesterol esterification both in human colonic adenocarcinoma L S180 cells and in human hepatoma HepG2 cells (IC50s = 150 and 330 nM, respectively).3 When fed as a dietary supplement (ED50 = 0.81 mg/kg/day), TMP-153 reduces hepatic cholesterogenesis in hamsters fed a stock diet.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Buhman, K.F.,Accad, M. and Farese, R.V., Jr. Mammalian acyl-CoA:cholesterol acyltransferases. Biochimica et Biophysica Acta 1529, 142-154 (2000).
2.Sugiyama, Y.,Odaka, H.,Itokawa, S., et al. TMP-153, a novel ACAT inhibitor, lowers plasma cholesterol through its hepatic action in Golden hamsters. Atherosclerosis 118, 145-153 (1995).
3.Sugiyama, Y.,Ishikawa, E.,Odaka, H., et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis 113, 71-78 (1995).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 437.9 |
| 分子式 | C24H18ClF2N3O |
| CAS号 | 128831-46-9 |
| 稳定性 | ≥ 2 years |
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