ZM 336372
货号：
10010367-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010367-1mg |
| 描述 | The Ras/Raf-1 signalling pathway is a well-characterized system that links receptor tyrosine kinase (RTK) activation with changes in gene expression and cell behavior. Raf-1 is a serine/threonine protein kinase that phosphorylates and activates MAPK-kinase (MEK) in response to activation by Ras. ZM 336372 is a potent ATP-competitive inhibitor of Raf-1 in vitro(IC50 = 70 nM) with the paradoxical effect of inducing >100-fold activation of Raf-1 in whole cells.1 Activation of the Raf-1 signalling pathway using ZM 336372 in human carcinoid tumor cells results in induction of cell cycle inhibitors and suppression of cellular proliferation.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hall-Jackson, C.A.,Eyers, P.A.,Cohen, P., et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chemistry & Biology 6, 559-568 (1999).
2.Van Gompel, J.J.,Kunnimalaiyaan, M.,Holen, K., et al. ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Molecular Cancer Therapeutics 4(6), 910-917 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | >98% |
| 计算分子量 | 389.4 |
| 分子式 | C23H23N3O3 |
| CAS号 | 208260-29-1 |
| 稳定性 | ≥ 2 years |
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