Harmine
货号：
10010324-250mg 基本售价：
350.0 元 规格：
250 mg
产品信息
概述| 货号 | 10010324-250mg |
| 描述 | Peroxisome proliferator-activated receptor γ (PPARγ) is a central regulator of adipocyte differentiation and is the principle target of the thiazolidinedione (TZD) class of antidiabetic drugs.1 Harmine is a β-carboline alkaloid that was first isolated from seeds of Peganum harmala (Syrian rue) and Banisteriopsis caapi. Recent work indicates that harmine is a unique regulator of PPARγ expression that acts by inhibiting the Wnt signalling pathway in a cell-specific manner.2 Administration of harmine (30 mg/kg) to obese db/db mice resulted in reduced blood glucose, free fatty acids, and triglyceride levels, delayed hyperglycemia, and improved insulin sensitivity. Harmine also attenuates inflammatory gene expression (TNFα, IL-1β, iNOS) and macrophage accumulation in adipose tissue.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hauner, H. The mode of action of thiazolidinediones. Diabetes/Metabolism Research and Reviews 18, S10-S15 (2002).
2.Waki, H.,Park, K.W.,Mitro, N., et al. The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARγ expression. Cell Metabolism 5, 357-370 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 212.3 |
| 分子式 | C13H12N2O |
| CAS号 | 442-51-3 |
| 稳定性 | ≥ 2 years |
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