| 货号 | 10009965-1mg |
| 描述 | VO-OHpic is a specific inhibitor of phosphatase and tensin homolog (PTEN; IC50 = 35 nM in vitro).1,2 Through this action, it increases cellular phosphatidylinositol 3,4,5-trisphosphate (PIP3) levels, phosphorylation of Akt, and glucose uptake in adipocytes.1 In mice, VO-OHpic (10 µg/kg, i.p.) decreases left ventricular systolic pressure and heart rate and protects against ischemia/reperfusion-induced myocardial infarction.3 VO-OHpic also blocks the development of suppressor activity in regulatory T cells activated with indoleamine 2,3-dioxygenase.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Rosivatz, E.,Matthews, J.G.,McDonald, N.Q., et al. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1(12), 780-790 (2006). 2.Mak, L.H.,Vilar, R., and Woscholski, R. Characterisation of the PTEN inhibitor VO-OHpic. J. Chem. Biol. 3(4), 157-163 (2010). 3.Zu, L.,Shen, Z.,Wesley, J., et al. PTEN inhibitors cause a negative inotropic and chronotropic effect in mice. Eur. J. Pharmacol. 650(1), 298-302 (2011). 4.Sharma, M.D.,Shinde, R.,McGaha, T.L., et al. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci. Adv. 1(10), e1500845 (2015). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 415.2 |
| 分子式 | C12H9N2O8V • H [3H2O] |
| CAS号 | 476310-60-8 |
| 稳定性 | ≥ 2 years |
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