EX-527
货号：
10009798-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009798-1mg |
| 描述 | Mammalian sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in energy metabolism and inflammation. EX-527 is a cell-permeable, selective inhibitor of SIRT1 (IC50 = 98 nM).1 It inhibits other SIRTs only at much higher concentrations and has no effect on other HDACs. EX-527 has been used to investigate the relationship between SIRT1-mediated deacetylation of p53, p53 activity, and cell survival following DNA damage.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nayagam, V.M.,Wang, X.,Tan, Y.C., et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. Journal of Biomolecular Screening 11(8), 959-967 (2006).
2.Solomon, J.M.,Pasupuleti, R.,Xu, L., et al. Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Molecular and Cellular Biology 26(1), 28-38 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 248.7 |
| 分子式 | C13H13ClN2O |
| CAS号 | 49843-98-3 |
| 稳定性 | ≥ 2 years |
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