G-1
货号：
10008933-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10008933-1mg |
| 描述 | GPR30 is a transmembrane G protein-coupled receptor (GPCR) localized to endoplasmic reticulum (ER) that binds estradiol with high affinity, activating multiple intracellular signaling pathways.1 G-1 is a nonsteroidal, high-affinity, selective agonist of GPR30 that binds with a Ki value of 11 nM. Competitive binding studies in endoplasmic reticulum α- (ERα-) and ERβ-expressing cells yielded Ki values for estradiol of 0.30 and 0.38 nM, respectively, with no substantial binding of G-1 at 1 µM.2 The discovery of G-1, a compound that does not bind classical ERs, should facilitate further physiological experiments to define the role of GPR30 in vivo. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Revankar, C.M.,Cimino, D.F.,Sklar, L.A., et al. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307, 1625-1630 (2005).
2.Bologa, C.G.,Revankar, C.M.,Young, S.M., et al. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature Chemical Biology 2(4), 207-212 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 412.3 |
| 分子式 | C21H18BrNO3 |
| CAS号 | 881639-98-1 |
| 稳定性 | ≥ 2 years |
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