| 货号 | 10008884-10mg |
| 描述 | Fish oils in the diet have anti-inflammatory and cardiovascular benefits due to an abundance of ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid (EPA).1 EPA ethyl ester is a stabilized ethyl ester form of this ω-3 C20:5 PUFA. EPA competitively inhibits the metabolism of (ω-6) arachidonic acid by cyclooxygenase enzymes,2 suggesting that EPA ethyl ester may also directly modulate the actions of enzymes involved in fatty acid metabolism. In addition, dietary EPA ethyl ester in rats increases fatty acid β-oxidation enzyme levels,3,4 indicating that EPA ethyl ester may alter the expression of genes related to fatty acid metabolism. Consistent with this concept, dietary supplementation with EPA ethyl ester in rats also down-regulates lipogenic genes, and decreases plasma cholesterol and triglyceride levels.5 Also, in rats fed a high-fat diet, supplementation with EPA ethyl ester blocks induced insulin resistance and corrects changes in adiponectin levels and TNF-α expression.6 |
| 别名 | EPA ethyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.von Schacky, C. A review of omega-3 ethyl esters for cardiovascular prevention and treatment of increased blood triglyceride levels. Vascular Health and Risk Management 2(3), 251-262 (2006). 2.Wada, M.,DeLong, C.J.,Hong, Y.H., et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. The Journal of Biological Chemisty 282(31), 22254-22266 (2007). 3.Hong, D.D.,Takahashi, Y.,Kushiro, M., et al. Divergent effects of eicosapentaenoic and docosahexaenoic acid ethyl esters, and fish oil on hepatic fatty acid oxidation in the rat. Biochimica et Biophysica Acta 1635, 29-36 (2003). 4.Arachchige, P.G.,Takahashi, Y., and Ide, T. Dietary sesamin and docosahexaenoic and eicosapentaenoic acids synergistically increase the gene expression of enzymes involved in hepatic peroxisomal fatty acid oxidation in rats. Metabolism: Clinical and Experimental 55, 381-390 (2006). 5.Pérez-Echarri, N.,Pérez-Matute, P.,Marcos-Gómez, B., et al. Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats. Journal of Nutritional Biochemistry (2008). 6.Pérez-Matute, P.,Pérez-Echarri, N.,Martínez, J.A., et al. Eicosapentaenoic acid actions on adiposity and insulin resistance in control and high-fat-fed rats: Role of apoptosis, adiponectin and tumor necrosis factor-α. British Journal of Nutrition 97, 389-398 (2007). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 330.5 |
| 分子式 | C22H34O2 |
| CAS号 | 86227-47-6 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |