| 货号 | 10008042-50ug |
| 描述 | Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2; Item No. 10037), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARγ and can also decompose or be metabolized to release nitric oxide.1,2,3,4 9-Nitrooleate is one of two regioisomers of nitrooleate, the other being 10-nitrooleate (Item No. 10008043) (OA-NO2; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo.5 Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARγ approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM.5 |
| 别名 | 9-Nitrooleic Acid;9-nitro-9-trans-Octadecenoic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lim, D.G.,Sweeney, S.,Bloodsworth, A., et al. Nitrolinoleate, a nitric oxide-derived mediator of cell function: Synthesis, characterization, and vasomotor activity. Proceedings of the National Academy of Sciences of the United States of America 99(25), 15941-15946 (2002). 2.Schopfer, F.J.,Lin, Y.,Baker, P.R.S., et al. Nitrolinoleic acid: An endogenous peroxisome proliferator-activated receptor g ligand. Proceedings of the National Academy of Sciences of the United States of America 102(7), 2340-2345 (2005). 3.Lima, E.S.,Bonini, M.G.,Augusto, O., et al. Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxation. Free Radical Biology & Medicine 39, 532-539 (2005). 4.Baker, P.R.S.,Schopfer, F.J.,Sweeney, S., et al. Red cell membrane and plasma linoleic acid nitration products: Synthesis, clinical identification, and quantitation. Proceedings of the National Academy of Sciences of the United States of America 101(32), 11577-11582 (2004). 5.Baker, P.R.,Lin, Y.,Schopfer, F.J., et al. Fatty acid transduction of nitric oxide signaling. Multiple nitrated unsaturated acid derivatives exist in human blood and urine serve as endogenous peroxisome proliferator-activated receptor ligands. The Journal of Biological Chemisty 280(51), 42464-42475 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 327.5 |
| 分子式 | C18H33NO4 |
| CAS号 | 875685-44-2 |
| 稳定性 | ≥ 1 year |
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