5α-hydroxy-6-keto Cholesterol
货号：
10007601-1mg 基本售价：
350.0 元 规格：
1 mg
产品信息
概述| 货号 | 10007601-1mg |
| 描述 | Cholesterol is the most abundant neutral lipid present in the surfactant of the lung epithelial lining fluid. The double bond between carbons 5 and 6 of cholesterol is susceptible to attack by ozone within this surfactant environment. 5α-hydroxy-6-keto Cholesterol (6-oxo-3,5,-diol) is a major metabolite of cholesterol formed during exposure of lung epithelial cells to ozone, with formation of 5β,6β-epoxycholesterol as a predominant precursor.1 Exposure of C57BL/6J mice to 0.5-3 ppm ozone produced a dose-dependent formation of 6-oxo-3,5,-diol which was detectable in the bronchalveolar lavage fluid, lavaged cells, and lung homogenates.2 6-Oxo-3,5-diol is a potent inhibitor of cholesterol synthesis in human bronchial epithelial cells with an IC50 of 350 nM and exhibits significant cytotoxicity in the low µM range.1 Therefore, the toxic effects of ozone may be mediated by formation oxysterols of this type. |
| 别名 | 6-Oxo-3,5-diol;Cholestane-6-oxo-3β,5α-diol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pulfer, M.K., and Murphy, R.C. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. The Journal of Biological Chemisty 279(25), 26331-26338 (2004).
2.Pulfer, M.K.,Taube, C.,Gelfand, E., et al. Ozone exposure in vivo and formation of biologically active oxysterols in the lung. Journal of Pharmacology and Experimental Therapeutics 312(1), 256-264 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 418.7 |
| 分子式 | C27H46O3 |
| CAS号 | 13027-33-3 |
| 稳定性 | ≥ 2 years |
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