| 货号 | 89290-10mg |
| 描述 | 8-hydroxy Guanine is produced by oxidative damage of DNA or RNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.1,2,3,4,5 |
| 别名 | NSC 22720;8-Oxoguanine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beckman, K.B. and Ames, B.N. Oxidative decay of DNA. The Journal of Biological Chemisty 272, 19633-19636 (1997). 2.Park, E.M.,Shigenaga, M.K.,Degan, P., et al. Assay of excised oxidative DNA lesions: Isolation of 8-oxoguanine and its nucleoside derivatives from biological fluids with a monoclonal antibody column. Proceedings of the National Academy of Sciences of the United States of America 89, 3375-3379 (1992). 3.Jaruga, P.,Zastawny, T.H.,Skokowski, J., et al. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Letters 341, 59-64 (1994). 4.Spencer, J.P.E.,Jenner, A.,Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Letters 374, 233-236 (1995). 5.Epe, B.,Ballmaier, D.,Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Research 24, 4105-4110 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥90% |
| 计算分子量 | 203.6 |
| 分子式 | C5H5N5O2 • HCl |
| CAS号 | 1246818-54-1 |
| 稳定性 | ≥ 1 year |
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