| 货号 | 21687-250mg |
| 描述 | N(G)-Nitro-D-arginine methyl ester (D-NAME) is the less active enantiomer of the nitric oxide (NO) synthase inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME; Item No. 80210). D-NAME was initially thought to be inactive and was often used as a negative control for L-NAME.1,2 Later studies showed that D-NAME (40 mg/kg/day in rats) can have similar but less pronounced effects as L-NAME (40 mg/kg/day in rats) in the cardiovascular system, particularly at long-term timepoints.3 D-NAME (3-10 µg/mouse) had no effect on nociception in mice assessed using the tail flick test.4 |
| 别名 | D-NG-Nitroarginine methyl ester;N(G)-Nitro-D-Arginine methyl ester; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Palmer, R.M.J.,Rees, D.D.,Ashton, D.S., et al. L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation. Biochem. Biophys. Res. Commun. 153(3), 1251-1256 (1988). 2.Chinellato, A.,Froldi, G.,Caparrota, L., et al. Pharmacological characterization of endothelial cell nitric oxide synthase inhibitors in isolated rabbit aorta. Life Sci. 62(6), 479-490 (1998). 3.Babál, P.,Pechánová, O. and Bernátová, I. Long-term administration of D-NAME induces hemodynamic and structural changes in the cardiovascular system. Physiol. Res. 49(1), 47-54 (2000). 4.Kawabata, A.,Umeda, N. and Takagaki, H. L-arginine exerts a dual role in nociceptive processing in the brain: Involvement of the kyotorphin-Met-enkephalin pathway and NO-cyclic GMP pathway. Br. J. Pharmacol. 109(1), 73-79 (1993). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 269.7 |
| 分子式 | C7H15N5O4 • HCl |
| CAS号 | 50912-92-0 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |