| 货号 | 17349-50mg |
| 描述 | Midodrine is a prodrug of the α1-adrenergic receptor agonist, 1-(2’,5’-dimethoxyphenyl)-2-aminoethanol (Kis= 2, 6.9, and 1.7 µM for α1A, α1B, α1D, respectively).1 After oral administration it is completely absorbed via the intestinal H+-coupled peptide transporter 1 and converted to the active form through cleavage of a glycine residue.2 At 1-5 mg/kg, midodrine can produce a dose-related increase in mean arterial pressure in normotensive rats and improve the orthostatic index in an experimental model of postural hypotension.3 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Altenbach, R.J.,Khilevich, A.,Meyer, M.D., et al. N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. Journal of Medicinal Chemistry 45, 4395-4397 (2002). 2.Tsuda, M.,Terada, T.,Irie, M., et al. Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. JPET 318(1), 455-460 (2006). 3.Dabasaki, T.,Shimojo, M.,Ishikawa, H., et al. Anti-hypotensive effects of M6434, an orally active α1-adrenoceptor agonist, in rats. Japan.J.Pharmacol. 59, 145-150 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 290.7 |
| 分子式 | C12H18N2O4 • HCl |
| CAS号 | 43218-56-0 |
| 稳定性 | ≥ 2 years |
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