| 货号 | 14534-1mg |
| 描述 | NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM).1 It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs.2,3 NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.4 |
| 别名 | NSC 696807; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Griffin, R.J.,Srinivasan, S.,Bowman, K., et al. Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP). Journal of Medicinal Chemistry 41(26), 5247-5256 (1998). 2.Bowman, K.J.,White, A.,Golding, B.T., et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. British Journal of Cancer 78(10), 1269-1277 (1998). 3.Delaney, C.A.,Wang, L.Z.,Kyle, S., et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clinical Cancer Research 6(7), 2860-2867 (2000). 4.Kumala, S.,Fujarewicz, K.,Jayaraju, D., et al. Repair of DNA strand breaks in a minichromosome in vivo: Kinetics, modeling, and effects of inhibitors. PLoS One 8(1), (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 176.2 |
| 分子式 | C9H8N2O2 |
| CAS号 | 90417-38-2 |
| 稳定性 | ≥ 2 years |
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