W-13 (hydrochloride)
货号：
14277-1mg 基本售价：
336.0 元 规格：
1 mg
产品信息
概述| 货号 | 14277-1mg |
| 描述 | W-13 is a naphthalenesulfonamide derivative that acts as a potent antagonist of calmodulin (IC50 = 22 μM) and is widely used to investigate Ca2+/calmodulin-regulated enzyme activities.1,2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Katayama, N.,Nishikawa, M.,Komada, F., et al. A role for calmodulin in the growth of human hematopoietic progenitor cells. Blood 75(7), 1446-1454 (1990).
2.Tebar, F.,Villalonga, P.,Sorkina, T., et al. Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway. Molecular Biology of the Cell 13(6), 2057-2068 (2002).
3.Sengupta, P.,Ruano, M.J.,Tebar, F., et al. Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: Dual effect of W-13 on epidermal growth factor receptor activation. The Journal of Biological Chemisty 282(11), 8474-8486 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 349.3 |
| 分子式 | C14H17ClN2O2S • HCl |
| CAS号 | 88519-57-7 |
| 稳定性 | ≥ 2 years |
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