| 货号 | 13021-5mg |
| 描述 | 2-methoxy Estradiol (2-ME2) is a natural metabolite formed by CYP450-mediated hydroxylation followed by catechol-O-methyltransferase (COMT) methylation of estradiol. Administration of 2-hydroxy estradiol (2-HE2) to rats results in formation and clearance of 2-ME2 with t½ values of 7.9 and 24.9 minutes, respectively.1 2-ME2 exhibits no affinity for estrogen receptors. 2-ME2 has achieved considerable attention as an anti-cancer agent acting as an angiogenesis inhibitor via the HIF-1α pathway.2,3,4 The levels of COMT and 2-ME2 are significantly lower in women with severe pre-eclampsia.5 |
| 别名 | 2-Hydroxyestradiol 2-methyl ether;2-ME2;NSC 659853;Panzem; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Zacharia, L.C.,Piché, C.A.,Fielding, R.M., et al. 2-hydroxyestradiol is a prodrug of 2-methoxyestradiol. Journal of Pharmacology and Experimental Therapeutics 309(3), 1093-1097 (2004). 2.Mooberry, S.L. New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent. Current Opinion in Oncology 15, 425-430 (2003). 3.Mooberry, S.L. Mechanism of action of 2-methoxyestradiol: New developments. Drug Resistance Updates 6, 355-361 (2003). 4.Becker, C.M.,Rohwer, N.,Funakoshi, T., et al. 2-methoxyestradiol inhibits hypoxia-inducible factor-1α and suppressess growth of lesions in a mouse model of endometriosis. American Journal of Pathology 172(2), 534-544 (2008). 5.Kanasaki, K.,Palmsten, K.,Sugimoto, H., et al. Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature 453, 1117-1123 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 302.4 |
| 分子式 | C19H26O3 |
| CAS号 | 362-07-2 |
| 稳定性 | ≥ 2 years |
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