Triptolide
货号：
11973-1mg 基本售价：
336.0 元 规格：
1 mg
产品信息
概述| 货号 | 11973-1mg |
| 描述 | Triptolide is the major bioactive constituent of T. wilfordii Hook F., also known as thunder god vine, a traditional Chinese medicinal herb with known antiproliferative, immunosuppressive, anti-inflammatory, antifertility, and anti-polycystic kidney disease effects. Triptolide binds to and inhibits human dCTP pyrophosphatase 1, a “gatekeeper” enzyme that prevents deleterious halogenated nucleotides from entering DNA synthesis, with a Ki value of 168 μM and an IC50 value of 7-10 nM.1 Triptolide has also been shown to inhibit LPS-stimulated induction of cyclooxygenase 2 mRNA and synthesis of prostaglandin E2 in human peripheral blood monocytes, rheumatoid arthritis synovial fibroblasts, and human neonatal foreskin fibroblasts with an IC50 value of 0.04 μM.2 |
| 别名 | NSC 163062;PG 490; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Corson, T.W.,Cavga, H.,Aberle, N., et al. Triptolide directly inhibits dCTP pyrophosphatase. ChemBioChem 12, 1767-1773 (2011).
2.Larsson, J.,Gottfries, J.,Bohlin, L., et al. Expanding the ChemGPS chemical space with natural products. Journal of Natural Products 68, 985-991 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 360.4 |
| 分子式 | C20H24O6 |
| CAS号 | 38748-32-2 |
| 稳定性 | ≥ 2 years |
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