Penicillic Acid
货号：
11440-5mg 基本售价：
336.0 元 规格：
5 mg
产品信息
概述| 货号 | 11440-5mg |
| 描述 | Gram negative bacteria utilize N-acylated homoserine lactones to coordinate expression of virulence in response to the density of the surrounding bacterial population in a process termed quorum sensing. By interfering with this communication and thereby disrupting virulence expression, quorum sensing inhibitors are emerging as an alternative to the conventional ways of fighting bacterial infections. Penicillic acid is a mycotoxin produced from Penicillium species identified in molds on corn and other grains. At 80 μM, penicillic acid inhibits bacterial quorum sensing communication in P. aeruginosa by selectively repressing various virulence factor and other quorum sensing-regulated genes.1 It has been shown to inhibit Fas-mediated apoptosis at 100-200 μM by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells.2 |
| 别名 | NSC 402844; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rasmussen, T.B.,Skindersoe, M.E.,Bjarnsholt, T., et al. Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology 151, 1325-1340 (2005).
2.Bando, M.,Hasegawa, M.,Tsuboi, Y., et al. The mycotoxin penicillic acid inhibits Fas ligand-induced apoptosis by blocking self-processing of caspase-8 in death-inducing signaling complex. The Journal of Biological Chemisty 278(8), 5786-5793 (2003).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 170.2 |
| 分子式 | C8H10O4 |
| CAS号 | 90-65-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
