| 货号 | 16474-1g |
| 描述 | Reserpine is an alkaloid isolated from dried roots of R. serpentine, which is used in traditional Indian medicine. Reserpine irreversibly inhibits both human isoforms of vesicular monoamine transporter, VMAT1 and VMAT2 (Kis = 34 and 12 nM, respectively).1,2 As this leads to metabolism of monoamines, reserpine is used to experimentally deplete monoamines in animals.3,4,5 Reserpine also inhibits the multidrug resistance protein P-glycoprotein (IC50 = 0.5 µM).6 |
| 别名 | NSC 59272;NSC 237659;Rausedil; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Schuldiner, S.,Liu, Y. and Edwards, R.H. Reserpine binding to a vesicular amine transporter expressed in Chinese hamster ovary fibroblasts. The Journal of Biological Chemisty 268(1), 29-34 (1993). 2.Erickson, J.D.,Schäfer, M.K.H.,Bonner, T.I., et al. Distinct pharmacological properties and distribution in neurons and endocrine cells of two isoforms of the human vesicular monoamine transporter. Proceedings of the National Academy of Sciences of the United States of America 93(10), 5166-5171 (1996). 3.Hu, X.T.,Wachtel, S.R.,Galloway, M.P., et al. Lesions of the nigrostriatal dopamine projection increase the inhibitory effects of D1 and D2 dopamine agonists on caudate-putamen neurons and relieve D2 receptors from the necessity of D1 receptor stimulation. Journal of Neuroscience 10(7), 2318-2329 (1990). 4.Stanwood, G.D.,Lucki, I. and McGonigle, P. Differential regulation of dopamine D2 and D3 receptors by chronic drug treatments. Journal of Pharmacology and Experimental Therapeutics 295(3), 1232-1240 (2000). 5.Matsumoto, K.,Mizowaki, M.,Suchitra, T., et al. Central antinociceptive effects of mitragynine in mice: Contribution of descending noradrenergic and serotonergic systems. European Journal of Pharmacology 317(1), 75-81 (1996). 6.Wang, E.j.,Lew, K.,Barecki, M., et al. Quantitative distinctions of active site molecular recognition by P-glycoprotein and cytochrome P450 3A4. Chemical Research in Toxicology 14(12), 1596-1603 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 608.7 |
| 分子式 | C33H40N2O9 |
| CAS号 | 50-55-5 |
| 稳定性 | ≥ 2 years |
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