Itraconazole
货号：
13288-25mg 基本售价：
322.0 元 规格：
25 mg
产品信息
概述| 货号 | 13288-25mg |
| 描述 | The Hedgehog signaling pathway is critical for embryonic growth and patterning as well as stem cell and progenitor cell tissue homeostasis. Inappropriate Hedgehog activity has been linked to tumor formation.1 Itraconazole is a systemic antifungal agent with a distinct antagonist effect on Hedgehog signaling. With an IC50 value of 0.8 μM in vitro, itraconazole behaves as an inverse agonist downstream of Patched (Ptch), yet upstream of Smoothened (Smo) to disrupt Hedgehog signaling.2 Treatment with 100 mg/kg itraconazole twice per day has been shown to suppress the growth of medulloblastomas from a Ptch+/-p53-/- mouse allograft model in as few as five days.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Mahindroo, N.,Punchihewa, C. and Fujii, N. Hedgehog-Gli signaling pathway inhibitors as anticancer agents. Journal of Medicinal Chemistry 52(13), 3829-3845 (2009).
2.Kim, J.,Tang, J.Y.,Gong, R., et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17, 388-399 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 705.6 |
| 分子式 | C35H38Cl2N8O4 |
| CAS号 | 84625-61-6 |
| 稳定性 | ≥ 2 years |
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