| 货号 | 13124-1mg |
| 描述 | The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development.1,2,3 BIX01294 (hydrochloride hydrate) is a selective inhibitor of G9a HMTase (IC50 = 1.7 μM).4 It less effectively inhibits the HMTase G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known HMTases.4 BIX01294 has been used in combination with the calcium channel activator BayK8644 to facilitate the generation of induced pluripotent stem cells from somatic cells in vitro.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tachibana, M.,Sugimoto, K.,Nozaki, M., et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes & Development 16, 1779-1791 (2002). 2.Wagschal, A.,Sutherland, H.G.,Woodfine, K., et al. G9a histone methyltransferase contributes to imprinting in the mouse placenta. Molecular and Cellular Biology 28(3), 1104-1113 (2008). 3.Thomas, L.R.,Miyashita, H.,Cobb, R.M., et al. Functional analysis of histone methyltransferase G9a in B and T lymphocytes. Journal of Immunology 181, 485-493 (2008). 4.Kubicek, S.,OSullivan, R.J.,August, E.M., et al. Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase. Molecular Cell 25, 473-481 (2007). 5.Shi, Y.,Desponts, C.,Do, J.T., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell 3(5), 568-574 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 600 |
| 分子式 | C28H38N6O2 • 3HCl [XH2O] |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |