| 货号 | 11750-5g |
| 描述 | Piperine is a natural alkaloid that can be isolated from black pepper. It activates transient receptor potential vanilloid type 1 receptor (TRPV1; EC50 = 38 µM) and modulates GABAA receptors (EC50s = 43-60 µM).1,2 At similar levels, piperine inhibits both monoamine oxidases (MAOs), with IC50 values of 21 and 7 µM for MAO-A and MAO-B, respectively.3 Like other natural compounds containing methylenedioxyphenyl substituents, piperine affects cytochrome P450 (CYP) isoforms, inhibiting CYP3A species (Ki ~ 5 µM) and increasing expression of CYP1A and CYP2B in liver.4 It also has a biphasic effect on P-glycoprotein activity.5 |
| 别名 | Bioperine;NSC 21727;N-Piperoylpiperidin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.McNamara, F.N.,Randall, A., and Gunthorpe, M.J. Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). British Journal of Pharmacology 144(6), 781-790 (2005). 2.Schöffmann, A.,Wimmer, L.,Goldman, D., et al. Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives. Journal of Medicinal Chemistry 57(37), 5602-5619 (2014). 3.Lee, S.A.,Hong, S.S.,Han, X.H., et al. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chem.Pharm.Bull.(Tokyo) 53(7), 832-835 (2005). 4.Murray, M. Toxicological actions of plant-derived and anthropogenic methylenedioxyphenyl-substituted chemicals in mammals and insects. J.Toxicol.Environ.Health B.Crit.Rev. 15(6), 365-395 (2012). 5.Najar, I.A.,Sachin, B.S.,Sharma, S.C., et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytotherapy Research 24(3), 454-458 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.3 |
| 分子式 | C17H19NO3 |
| CAS号 | 94-62-2 |
| 稳定性 | ≥ 2 years |
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