Glipizide
货号：
11579-1g 基本售价：
322.0 元 规格：
1 g
产品信息
概述| 货号 | 11579-1g |
| 描述 | Glipizide is a short-acting, second-generation, blood-glucose-lowering agent belonging to the sulfonylurea class that increases the release of endogenous insulin from β-cells by blocking potassium channels.1 The drug-formulated version of Glipizide, marketed as Glucotrol or under generic label, is most commonly prescribed to lower blood sugar levels in type 2 diabetes (non-insulin-dependent diabetes mellitus). It is a weak acid (pKa = 5.9) that is better absorbed in acidic medium.2 However, its aqueous solubility is limited at very low pH values, causing large variations in bioavailability.2 |
| 别名 | Aldiab;CP 28720;Digrin;Glucotrol;K 4024;Ozidia;TK 1320; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Melander, A. Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes. Diabetes 53, S151-S155 (2004).
2.Tan, Z.,Zhang, J.,Wu, J., et al. The enhancing effect of ion-pairing on the skin permeation of glipizide. AAPS PharmSciTech 10(3), 967-976 (2009).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 445.4 |
| 分子式 | C21H27N5O4S |
| CAS号 | 29094-61-9 |
| 稳定性 | ≥ 2 years |
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