CAY10654
货号：
10857-1mg 基本售价：
322.0 元 规格：
1 mg
产品信息
概述| 货号 | 10857-1mg |
| 描述 | The gram-negative pathogen Pseudomonas aeruginosa uses N-acylated-L-homoserine lactones (AHLs) in quorum sensing to modulate transcriptional activators, including LasR, and regulate the expression of virulence factors. The same AHLs suppress the host immune system. CAY10654 is a synthetic analog of natural AHLs that suppresses host immunity without inducing LasR.1 It inhibits the proliferation of mouse peripheral blood leukocytes by concanavalin A (EC50 = 9.3 μM) without concurrent cytotoxicity.1 LasR is not induced by 100 μM CAY10654, although LasR is potently induced by natural AHL (5 μM) in positive control experiments.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jadhav, G.P.,Chhabra, S.R.,Telford, G., et al. Immunosuppressive but non-LasR-inducing analogues of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone. Journal of Medicinal Chemistry 54(9), 3348-3359 (2011).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 340.9 |
| 分子式 | C17H25ClN2O3 |
| CAS号 | 1298023-69-4 |
| 稳定性 | ≥ 2 years |
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