| 货号 | 10011211-500ug |
| 描述 | Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor found predominantly in the liver that is involved in the regulation of lipid homeostasis.1,2 Activation of PPARα results in expression of a variety of genes, particularly those involved in fatty acid β-oxidation, binding, and transport. 3 GW 9578 is a potent agonist of PPARα that activates the murine and human receptors with EC50 values of 0.005 and 0.05 µM, respectively.4 GW 9578 is highly selective for PPARα compared to PPARγ and PPARδ, which it activates in murine at EC50 values of 0.15 and 2.6 µM, respectively and in human at 1.0 and 1.4 µM, respectively.4 GW 9578 is a potent lipid lowering agent that may reduce insulin resistance. When 0.2 mg/kg GW 9578 was given orally once daily for three days, serum total LDL cholesterol was decreased 40-60% in male Sprague-Dawely rats.4 Obese Zucker rats treated with 5 mg/kg GW 9578 for nine days had markedly reduced serum insulin concentrations compared to controls.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Latruffe, N., and Vamecq, J. Peroxisome proliferators and peroxisome proliferator activated receptors (PPARs) as regulators of lipid metabolism. Biochimie 79, 81-94 (1997). 2.Lemberger, T.,Desvergne, B., and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annual Reviews of Cell Development and Biology 12, 335-363 (1996). 3.Mandard, S.,Müller, M., and Kersten, S. Peroxisome proliferator-activated receptor α target genes. Cellular and Molecular Life Sciences 61, 393-416 (2004). 4.Brown, P.J.,Winegar, D.A.,Plunket, K.D., et al. A ureido-thioisobutyric acid (GW9578) is a subtype-selective PPARα agonist with potent lipid-lowering activity. Journal of Medicinal Chemistry 42, 3785-3788 (1999). 5.Guerre-Millo, M.,Gervois, P.,Raspé, E., et al. Peroxisome proliferator-activated receptor α activators improve insulin sensitivity and reduce adiposity. The Journal of Biological Chemisty 275, 16638-16642 (2000). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 492.6 |
| 分子式 | C26H34F2N2O3S |
| CAS号 | 247923-29-1 |
| 稳定性 | ≥ 1 year |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |