PI-103
货号：
10009209-1mg 基本售价：
322.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009209-1mg |
| 描述 | The phosphatidylinositol 3-kinases (PI3K) family of enzymes is comprised of 15 members that are divided into 3 classes according to their structure, substrate specificity, and mode of regulation.1,2 PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR. The IC50 values are 2, 8, 20, 26, 48, 83, 88, 150 nM for DNA-PK, p110α, mTORC1, PI3-KC2β, p110δ, mTORC2, p110β, and p110γ, respectively.1 PI-103 exhibits antiproliferative activity against a panel of glioma cell lines in vitro at a concentration of 0.5 µM. It also inhibits growth of established human glioma tumor xenografts in vivo with no observable toxicity.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Knight, Z.A.,Gonzalez, B.,Feldman, M.E., et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125, 733-747 (2006).
2.Rückle, T.,Schwarz, M.K., and Rommel, C. PI3Kγ inhibition: Towards an aspirin of the 21st century? Nature Reviews.Drug Discovery 5, 903-918 (2006).
3.Fan, Q.W.,Knight, Z.A.,Goldenberg, D.D., et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9, 341-349 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 348.4 |
| 分子式 | C19H16N4O3 |
| CAS号 | 371935-74-9 |
| 稳定性 | ≥ 2 years |
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