R-Palmitoyl-(2-methyl) Ethanolamide
货号：
90357-5mg 基本售价：
308.0 元 规格：
5 mg
产品信息
概述| 货号 | 90357-5mg |
| 描述 | R-Palmitoyl-(2-methyl) ethanolamide (RP-2ME) is a metabolically stable analog of the anti-inflammatory endogenous cannabinoid, palmitoyl ethanolamide (PEA). PEA is an endogenous cannabinoid found in brain, liver, and other mammalian tissues.1 PEA has also been isolated from egg yolk, and found to have anti-anaphylactic and anti-inflammatory activity in vitro.2 RP-2ME is a synthetic analog of PEA which incorporates an (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. RP-2ME inhibits FAAH-mediated hydrolysis of AEA by 54% at a concentration of 100 µM.3 It also has weak CB receptor affinity, in that 100 µM inhibits agonist binding (1 nM CP 55,940 or WIN 55,212-2) only 26% and 15.5% at the human CB1 and CB2 receptors, respectively.3 |
| 别名 | RP-2ME; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bachur, N.R.,Masek, K.,Melmon, K.L., et al. Fatty acid amides of ethanolamine in mammalian tissues. The Journal of Biological Chemisty 240, 1019-1024 (1965).
2.Ganley, O.H.,Graessle, O.E.,Robinson, H.J., et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin. Journal of Laboratory and Clinical Medicine 51, 709-714 (1958).
3.Jonsson, K.O.,Vandevoorde, S.,Lambert, D.M., et al. Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide. British Journal of Pharmacology 133, 1263-1275 (2001).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 313.5 |
| 分子式 | C19H39NO2 |
| CAS号 | 179951-56-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
