| 货号 | 70790-50g |
| 描述 | PPARγ is a ligand-activated transcription factor involved in the regulation of lipid homeostasis and may function as a master regulator of adipogenesis.1,2,3,4 Ligands for PPARγ include antidiabetic drugs of the thiazolidinedione structural class, 15-deoxy-Δ12,14-prostaglandin J2, and NSAIDS.5,6,7,8 BADGE is a synthetic compound used in the production of polycarbonate and industrial plastics. This compound was recently identified as an antagonist of PPARγ.9 BADGE binds to PPARγ with an apparent Kd of 100 µM and interferes with the ability of 3T3-L1 and 3T3-F442A cells to undergo hormone-mediated cell differentiation.9 |
| 别名 | Bisphenol A diglycidyl ether; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Elbrecht, A.,Chen, Y.,Cullinan, C.A., et al. Molecular cloning, expression and characterization of human peroxisome proliferator activated receptors γ 1 and γ 2. Biochemical and Biophysical Research Communications 224, 431-437 (1996). 2.Greene, M.E.,Blumberg, B.,McBride, O.W., et al. Isolation of the human peroxisome proliferator activated receptor γ cDNA: Expression in hematopoietic cells and chromosomal mapping. Gene Expression 4, 281-299 (1995). 3.Spiegelman, B.M. and Flier, J.S. Adipogenesis and obesity: Rounding out the big picture. Cell 87, 377-389 (1995). 4.Lemberger, T.,Desvergne, B. and Wahli, W. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology. Annual Reviews of Cell Development and Biology 12, 335-363 (1996). 5.Lehmann, J.M.,Moore, L.B.,Smith-Oliver, T.A., et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953-12956 (1995). 6.Willson, T.M.,Cobb, J.E.,Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J. Med. Chem. 39, 665-668 (1996). 7.Forman, B.M.,Tontonoz, P.,Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83, 803-812 (1995). 8.Lehmann, J.M.,Lenhard, J.M.,Oliver, B.B., et al. Peroxisome proliferator-activated receptors α and g are activated by indomethacin and other non-steroidal anti-inflammatory drugs. The Journal of Biological Chemisty 272, 3406-3410 (1997). 9.Wright, H.M.,Clish, C.B.,Mikami, T., et al. A synthetic antagonist for the peroxisome proliferator-activated receptor γ inhibits adipocyte differentiation. The Journal of Biological Chemisty 275, 1873-1877 (2000). | |
| 运输条件 | Ambient in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥85% |
| 计算分子量 | 340.4 |
| 分子式 | C21H24O4 |
| CAS号 | 1675-54-3 |
| 稳定性 | ≥ 1 year |
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