Thioetheramide-PC
货号：
62750-1mg 基本售价：
308.0 元 规格：
1 mg
产品信息
概述| 货号 | 62750-1mg |
| 描述 | Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2(sPLA2).1,2 The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.1 In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.1 |
| 别名 | 1-Palmitylthio-2-palmitoylamido-1,2-dideoxy-sn-glycero-3-phosphorylcholine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, L.,Deems, R.A.,Hajdu, J., et al. The interaction of phospholipase A2 with phospholipid analogues and inhibitors. The Journal of Biological Chemisty 265, 2657-2664 (1990).
2.Plesniak, L.A.,Boegeman, S.C.,Segelke, B.W., et al. Interaction of phospholipase A2 with thioether amide containing phospholipid analogues. Biochemistry 32, 5009-5016 (1993).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 735.1 |
| 分子式 | C40H83N2O5PS |
| CAS号 | 116457-99-9 |
| 稳定性 | ≥ 1 year |
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