| 货号 | 48001-100ug |
| 描述 | Cholesteryl linoleate hydroperoxides are derived from the autoxidation of cholesteryl linoleate and contain a mixture of racemic 9- and 13-HpODE cholesteryl esters. Oxidative modification of LDL is suggested to play an important role in atherosclerosis. (±)9- and (±)13-HODE cholesteryl esters were originally extracted from atherosclerotic lesions and shown to be produced by Cu2+-catalyzed oxidation of LDL.1,2 Later studies determined that 15-LO, from rabbit reticulocytes and activated human monocytes, oxygenates cholesteryl linoleate to both 9- and 13-hydroperoxy linoleate cholesteryl esters.3,4 Cholesteryl ester hydroperoxides may be transferred from LDL to HDL, reduced to the corresponding hydroxides, and cleared via the liver.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brooks, C.J.W.,Harland, W.A.,Steel, G., et al. Lipids of human atheroma: Isolation of hydroxyoctadecadienoic acids from advanced aortal lesions. Biochimica et Biophysica Acta 202, 563-566 (1970). 2.Lenz, M.L.,Hughes, H.,Mitchell, J.R., et al. Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein. Journal of Lipid Research 31, 1043-1050 (1990). 3.Belkner, J.,Wiesner, R.,Kühn, H., et al. The oxygenation of cholesterol esters by the reticulocyte lipoxygenase. FEBS Letters 279, 110-114 (1991). 4.Folcik, V.A. and Cathcart, M.K. Predominance of esterified hydroperoxy-linoleic acid in human monocyte-oxidized LDL. Journal of Lipid Research 35, 1570-1582 (1994). 5.Sattler, W. and Stocker, R. Greater selective uptake by Hep G2 cells of high-density lipoprotein cholesteryl ester hydroperoxides than of unoxidized cholesteryl esters. Biochemistry Journal 294, 771-778 (1993). 6.Fluiter, K.,Vietsch, H.,Biessen, E.A.L., et al. Increased selective uptake in vivo and in vitro of oxidized cholesteryl esters from high-density lipoprotein by rat liver parenchymal cells. Biochemistry Journal 319, 471-476 (1996). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% hydroperoxide content |
| 计算分子量 | 681.1 |
| 分子式 | C45H76O4 |
| 稳定性 | ≥ 6 months |
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