| 货号 | 15416-25mg |
| 描述 | Pinacidil is a cyanoguanidine compound that acts as a potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively.1,2,3 It completely relaxes coronary artery rings preconstricted with serotonin (Item No. 14332; IC50 = 1.26 µM).4 Through this mechanism, pinacidil causes vascular relaxation, decreases peripheral vascular resistance, and reduces hypertension in animals and humans.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hermsmeyer, R.K. Pinacidil actions on ion channels in vascular muscle. Journal of Cardiovascular Pharmacology 12(Suppl 2), S17-S22 (1988). 2.Davis-Taber, R.,Molinari, E.J.,Altenbach, R.J., et al. [125I]A-312110, a novel high-affinity 1,4-dihydropyridine ATP-sensitive K+ channel opener: Characterization and pharmacology of binding. Molecular Pharmacology 64(1), 143-153 (2003). 3.Coghlan, M.J.,Carroll, W.A. and Gopalakrishnan, M. Recent developments in the biology and medicinal chemistry of potassium channel modulators: Update from a decade of progress. Journal of Medicinal Chemistry 44(11), 1627-1653 (2001). 4.Gollasch, M.,Bychkov, R.,Ried, C., et al. Pinacidil relaxes porcine and human coronary arteries by activating ATP-dependent potassium channels in smooth muscle cells. Journal of Pharmacology and Experimental Therapeutics 275(2), 681-692 (1995). 5.Cohen, M.L. and Kurz, K.D. Pinacidil-induced vascular relaxation: Comparison to other vasodilators and to classical mechanisms of vasodilation. Journal of Cardiovascular Pharmacology 12(Suppl 2), S5-S9 (1988). 6.Goldberg, M.R. Clinical pharmacology of pinacidil, a prototype for drugs that affect potassium channels. Journal of Cardiovascular Pharmacology 12(Suppl 2), S41-S47 (1988). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 263.4 |
| 分子式 | C13H19N5 • H2O |
| CAS号 | 85371-64-8 |
| 稳定性 | ≥ 2 years |
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