| 货号 | 14957-1mg |
| 描述 | Adenosine 5-(γ-thio)-triphosphate (lithium salt) is a stable analog of ATP that acts as a potent agonist of G protein-coupled P2Y2 and P2Y11 receptors (pEC50 = 5.52 for P2Y11).1 It has been used to identify kinase substrates, has been implemented as a reagent in the synthesis of DNA N-acetylglucosamine analogs, and can serve as a substrate for the RNA-stimulated nucleotide hydrolysis and RNA unwinding activities of eukaryotic initiation factor-4A.2,3,4 |
| 别名 | ATPγS; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jacobson, K.A.,Ivanov, A.A.,de Castro, S., et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009). 2.Knowles, J.R. Enzyme-catalyzed phosphoryl transfer reactions. Annual Reviews of Biochemistry 49, 877-919 (1980). 3.Chrysogelos, S.,Register, J.C., III and Griffith, J. The structure of recA protein-DNA filaments. 2 recA protein monomers unwind 17 base pairs of DNA by 11.5 degrees/base pair in the presence of adenosine 5-O-(3-thiotriphosphate). The Journal of Biological Chemisty 258(20), 12624-12631 (1983). 4.Peck, M.L. and Herschlag, D. Adenosine 5-O-(3-thio)triphosphate (ATPγS) is a substrate for the nucleotide hydrolysis and RNA unwinding activities of eukaryotic translation initiation factor elF4A. RNA 9(10), 1180-1187 (2003). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 551 |
| 分子式 | C10H16N5O12P3S • 4Li |
| CAS号 | 93839-89-5 |
| 稳定性 | ≥ 2 years |
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