| 货号 | 14000-5mg |
| 描述 | Auraptene is a coumarin derived from citrus plants that bears a geranyloxyl moiety at its C-7. It has anti-inflammatory, anti-carcinogenic, anti-bacterial, neuroprotective, and hepatoprotective activities.1,2,3,4,5 It inhibits leukocyte activation and induces phase II enzymes during the initiation phase of carcinogenesis.1 When examined for its potential use in Alzheimer’s disease treatment, auraptene was shown to inhibit β-secretase (BACE1) activity with an IC50 value of 345.1 μM.6 |
| 别名 | 7-Geranyloxycoumarin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Murakami, A.,Nakamura, Y.,Tanaka, T., et al. Suppression by citrus auraptene of phorbol ester- and endotoxin-induced inflammatory responses: Role of attenuation of leukocyte activation. Carcinogenesis 21(10), 1843-1850 (2000). 2.Krishnan, P.,Yan, K.J.,Windler, D., et al. Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats. BMC Cancer 9, (2009). 3.Takeda, K.,Utsunomiya, H.,Kakiuchi, S., et al. Citrus auraptene reduces Helicobacter pylori colonization of glandular stomach lesions in Mongolian gerbils. J.Oleo Sci. 56(5), 253-260 (2007). 4.Furukawa, Y.,Watanabe, S.,Okuyama, S., et al. Neurotrophic effect of Citrus auraptene: Neuritogenic activity in PC12 cells. International Journal of Molecular Sciences 13, 5338-5347 (2012). 5.Sahebkar, A. Citrus auraptene: A potential multifunctional therapeutic agent for nonalcoholic fatty liver disease. Ann.Hepatol. 10(4), 575-577 (2011). 6.Marumoto, S. and Miyazawa, M. Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor. Bioorganic & Medicinal Chemistry 20(2), 784-788 (2012). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 298.4 |
| 分子式 | C19H22O3 |
| CAS号 | 495-02-3 |
| 稳定性 | ≥ 2 years |
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