ARP 100
货号：
13321-1mg 基本售价：
308.0 元 规格：
1 mg
产品信息
概述| 货号 | 13321-1mg |
| 描述 | Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration.1 During cancer progression both MMP-2 and MMP-9 play a role in metastatic tumor dispersion and angiogenesis. ARP 100 is a biphenylsulfonamide that acts as a selective inhibitor of MMP-2 demonstrating an IC50 value of 12 nM.2,3 Due to its specific zinc binding domain configuration, the inhibitory activity of ARP 100 is significantly less potent towards MMP-1, MMP-3, MMP-7, and MMP-9 (IC50 values are 50, 4.5, 50, and 2 µM, respectively).2,3 At 50 nM, ARP 100 suppresses the invasive behavior of HT1080 tumor cells grown on matrigel.2 |
| 别名 | CAY10609;Matrix Metalloproteinase-2 Inhibitor III;MMP-2 Inhibitor III; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nagase, H. and Woessner, J.F., Jr. Matrix metalloproteinases. The Journal of Biological Chemisty 274(31), 21491-21494 (1999).
2.Rossello, A.,Nuti, E.,Orlandini, E., et al. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorganic & Medicinal Chemistry 12, 2441-2450 (2004).
3.Tuccinardi, T.,Martinelli, A.,Nuti, E., et al. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorganic & Medicinal Chemistry 14, 4260-4276 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 364.4 |
| 分子式 | C17H20N2O5S |
| CAS号 | 704888-90-4 |
| 稳定性 | ≥ 2 years |
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