PF-3845
货号：
13279-1mg 基本售价：
308.0 元 规格：
1 mg
产品信息
概述| 货号 | 13279-1mg |
| 描述 | Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM).1 It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.1 PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ahn, K.,Johnson, D.S.,Mileni, M., et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & Biology 16, 411-420 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 456.5 |
| 分子式 | C24H23F3N4O2 |
| CAS号 | 1196109-52-0 |
| 稳定性 | ≥ 2 years |
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