| 货号 | 10976-25mg |
| 描述 | 10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees.1 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM.2 It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM.3,4 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.5,6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Kodai, T.,Umebayashi, K.,Nakatani, T., et al. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees (Apis mellifera). Chemical & Pharmaceutical Bulletin 55(10), 1528-1531 (2007). 2.Honda, Y.,Fujita, Y.,Maruyama, H., et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One 6(8), 1-10 (2011). 3.Wang, J.g.,Ruan, J.,Li, C.Y., et al. Connective tissue growth factor, a regulator related with 10-hydroxy-2-decenoic acid down-regulate MMPs in rheumatoid arthritis. Rheumatology International (2011). 4.Izuta, H.,Chikaraishi, Y.,Shimazawa, M., et al. 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. Evidence-Based Complementary and alternative Medicine 6(4), 489-494 (2009). 5.Hattori, N.,Nomoto, H.,Fukumitsu, H., et al. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed.Res. 28(5), 261-266 (2007). 6.Koya-Miyata, S.,Okamoto, I.,Ushio, S., et al. Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Bioscience, Biotechnology, and Biochemistry 68(4), 767-773 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 186.3 |
| 分子式 | C10H18O3 |
| CAS号 | 14113-05-4 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |