cis-ACCP
货号：
10012583-1mg 基本售价：
308.0 元 规格：
1 mg
产品信息
概述| 货号 | 10012583-1mg |
| 描述 | Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins, thus enabling cell migration.1 Overexpression of MMPs are linked to diseases such as cancer, arthritis, osteoporosis, and arteriosclerosis. cis-ACCP is a reversible and competitive inhibitor of type IV collagen-specific MMP-2 and MMP-9 with preference towards MMP-2 (IC50 = 4 and 20 µM, respectively).2 At 100 µM, cis-ACCP prevents 90% of tumor cell invasion across matrigel-coated membranes in vitro.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Nagase, H., and Woessner, J.F., Jr. Matrix metalloproteinases. The Journal of Biological Chemisty 274(31), 21491-21494 (1999).
2.Hoffman, A.,Qadri, B.,Frant, J., et al. Carbamoylphosphonate matrix metalloproteinase inhibitors 6: Cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic matrix metalloproteinase-2 selective inhibitor-synthesis and pharmacodynamic and pharmacokinetic analysis. Journal of Medicinal Chemistry 51, 1406-1414 (2008).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 222.2 |
| 分子式 | C7H15N2O4P |
| CAS号 | 777075-44-2 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
