| 货号 | 10011132-5mg |
| 描述 | Type 4 cyclic nucleotide phosphodiesterases (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Rolipram is a cell-permeable selective PDE4 inhibitor. Since PDE4 is abundant in leukocytes, rolipram inhibits inflammation by suppressing leukocyte function, inhibiting C5a-stimulated LTC4 synthesis in eosinophils (IC50 = 200 nM),1 and lipopolysaccharide-induced TNF synthesis in monocytes (IC50 = 360 nM).2 Rolipram also enhances neuronal survival,3 has antipsychotic effects in mice,4 and suppresses bone loss in ovariectomized rats.5 |
| 别名 | SB 95952;ZK 62711; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tenor, H.,Hatzelmann, A.,Church, M.K., et al. Effects of theophylline and rolipram on leukotriene C4(LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. British Journal of Pharmacology 118, 1727-1735 (1996). 2.Souness, J.E.,Griffin, M.,Maslen, C., et al. Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a low-affinity phosphodiesterase 4 conformer. British Journal of Pharmacology 118, 649-658 (1996). 3.Sasaki, T.,Kitagawa, K.,Omura-Matsuoka, E., et al. The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia. Stroke 38, 1597-1605 (2007). 4.Kanes, S.J.,Tokarczyk, J.,Siegel, S.J., et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience 144, 239-246 (2007). 5.Yao, W.,Tian, X.Y.,Chen, J., et al. Rolipram, a phosphodiesterase 4 inhibitor, prevented cancellous and cortical bone loss by inhibiting endosteal bone resorption and maintaining the elevated periosteal bone formation in adult ovariectomized rats. Journal of Musculoskeletal & Neuronal Interactions 7(2), 119-130 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 275.3 |
| 分子式 | C16H21NO3 |
| CAS号 | 61413-54-5 |
| 稳定性 | ≥ 2 years |
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