| 货号 | 10007897-500ug |
| 描述 | N-hexanoyl-L-Homoserine lactone-d3(C6-HSL-d3) contains three deuterium atoms at the C-6 position. It is intended for use as an internal standard for the quantification of C6-HSL by GC- or LC-mass spectrometry. Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. C6-HSL is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism.1 The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention, and septicemia in fish.2,3,4,5,6,7,8 |
| 别名 | C6-HSL-d3; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Gould, T.A.,Herman, J.,Krank, J., et al. Specificity of acyl-homoserine lactone syntheses examined by mass spectrometry. Journal of Bacteriology 188(2), 773-783 (2006). 2.Morohoshi, T.,Inaba, T.,Kato, N., et al. Identification of quorum-sensing signal molecules and the LuxRI homologs in fish pathogen edwardsiella tarda. Journal of Bioscience and Bioengineering 98(4), 274-281 (2004). 3.Ulrich, R.L.,Hines, H.B.,Parthasarathy, N., et al. Mutational analysis and biochemical characterization of the bukholderia thailandensis DW503 quorum-sensing network. Journal of Bacteriology 186(13), 4350-4360 (2004). 4.Wang, L.H.,Weng, L.X.,Dong, Y.H., et al. Specificity and enzyme kinetics of the quorum-quenching N-acyl homoserine lactone lactonase (AHL-lactonase). The Journal of Biological Chemisty 279(14), 13645-13651 (2004). 5.Yates, E.A.,Philipp, B.,Buckley, C., et al. N-acylhomoserine lactones undergo lactonolysis in a pH-temperature-, and acyl chain length-dependent manner during growth of yersinia pseudotuberculosis and pseudomonas aeruginosa. Infection and Immunity 70(10), 5635-5646 (2002). 6.Luo, Z.Q.,Su, S., and Farrand, S.K. In situ activation of the quorum-sensing transcription factor TraR by cognate and noncognate acyl-homoserine lactone ligands: Kinetics and consequences. Journal of Bacteriology 186(19), 5665-5672 (2003). 7.Christensen, A.B.,Riedel, K.,Eberl, L., et al. Quorum-sensing-directed protein expression in serratia proteamaculans B5a. Microbiology 149, 471-483 (2003). 8.Chambers, C.E.,Visser, M.B.,Schwab, U., et al. Identification of N-acylhomoserine lactones in mucopurulent respiratory secretions from cystic fibrosis patients. FEMS Microbiology Letters 244, 297-304 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% deuterated forms (d1-d3) |
| 计算分子量 | 200.3 |
| 分子式 | C10H12D3NO3 |
| 稳定性 | ≥ 1 year |
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