| 货号 | 14126-100mg |
| 描述 | Cycloheximide is a glutarimide antibiotic produced by S. griseus that inhibits protein synthesis in eukaryotes (IC50 = 5-50 μM) by interfering with translational elongation.1 Its effects on protein synthesis can either induce or inhibit apoptosis depending on cell type.2 Cycloheximide is widely used as a tool in molecular biology research for ribosome profiling and translational profiling as well as to determine the half-life of a protein.3,4 |
| 别名 | Naramycin A;NSC 185; |
| 是否危险品 | 是 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Obrig, T.G.,Culp, W.J.,McKeehan, W.L., et al. The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. The Journal of Biological Chemisty 246, 174-181 (1971). 2.Baskic, D.,Popovic, S.,Ristic, P., et al. Analysis of cycloheximide-induced apoptosis in human leukocytes: Fluorescence microscopy using annexin V/propidium iodide versus acridin orange/ethidium bromide. Cell Biology International 30, 924-932 (2006). 3.Lee, S.,Liu, B.,Lee, S., et al. Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution. Proceedings of the National Academy of Sciences of the United States of America 109(37), E2424-E2432 (2012). 4.Jiang, X.,Coffino, P. and Li, X. Development of a method for screening short-lived proteins using green fluorescent protein. Genome Biology 5(10), R81 (2004). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 281.4 |
| 分子式 | C15H23NO4 |
| CAS号 | 66-81-9 |
| 稳定性 | ≥ 2 years |
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