| 货号 | 63150-1mg |
| 描述 | Myriocin is an amino fatty acid antibiotic derived from certain thermophylic fungi, in this case Mycelia sterilia. It is a potent immunosuppressant having 10- to 100-fold more activity than cyclosporin A.1 Myriocin is a potent inhibitor of serine palmitoyltransferase (Ki = 0.28 nM), the enzyme that catalyzes the first step of sphingolipid biosynthesis. 2 It disrupts substratum adhesion of melanoma cells.3 It also suppresses cell proliferation in the murine cytotoxic T cell line CTLL-2 (IC50 = 15 nM) viaapoptosis.2,4 Myriocin suppresses replication of the hepatitis C virus in a murine model.5 |
| 别名 | ISP-1;Thermozymocidin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Fujita, T.,Inoue, K.,Yamamoto, S., et al. Fungal metabolites. Part 11. A potent immunosuppressive activity found in Isaria sinclairii metabolite. Journal of Antibiotics 47, 208-215 (1994). 2.Miyake, Y.,Kozutsumi, Y.,Nakamura, S., et al. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochemical and Biophysical Research Communications 211(2), 396-403 (1995). 3.Hidari, K.I.P.J.,Ichikawa, S.,Fujita, T., et al. Complete removal of sphingolipids from the plasma membrane disrupts cell to substratum adhesion of mouse melanoma cells. The Journal of Biological Chemisty 271(24), 14636-14641 (1996). 4.Nakamura, S.,Kozutsumi, Y.,Sun, Y., et al. Dual roles of sphingolipids in signaling of the escape from and onset of apoptosis in a mouse cytotoxic T-cell line, CTLL-2. The Journal of Biological Chemisty 271, 1255-1257 (1996). 5.Umehara, T.,Sudoh, M.,Yasui, F., et al. Serine palmitoyltransferase inhibitor suppresses HCV replication in a mouse model. Biochemical and Biophysical Research Communications 346, 67-73 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 401.5 |
| 分子式 | C21H39NO6 |
| CAS号 | 35891-70-4 |
| 稳定性 | ≥ 2 years |
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